Cytotoxic effect of potential probiotic Lactiplantibacillus plantarum KUMS-Y8 isolated from traditional dairy samples on the KB and OSCC human cancer cell lines

Oral cancer is one of the leading causes death worldwide, and its prevalence especially high in developing countries. As an oral treatment, traditional therapies are commonly used. Nonetheless, these treatments frequently result a variety side effects. consequence, there urgent need to enhance therapies. Probiotics have recently demonstrated intriguing properties as therapeutic options for treatment. Thus, purpose this study was investigate anticancer effect probiotic Lactobacillus strains on mouth epidermal carcinoma cells (KB) squamous cell (OSCC) lines. In study, we looked at 21 isolated from dairy products Kermanshah province western Iran see if they had any inhibitory effects lines vitro. We characterized before assessing comparing their potential safety. Using MTT assay, bacterial extract then prepared used anti-proliferative agent (KB OSCC) normal (fibroblast human umbilical vein endothelial (HUVEK) Finally, acridine orange/ethidium bromide staining determine whether caused by apoptosis. Four isolates (C14, M22, M42, Y8) were shown beneficial qualities. extracts (of protein nature) decreased survival proliferation KB OSCC (dose- time-dependent) inducing apoptosis, with no basic damaging cells. The revealed that Furthermore, four examined, isolate Y8 (Lactiplantibacillus plantarum) showed strongest suppressing when compared medicines (doxorubicin paclitaxel). current research found might reduce growth viability increasing rate patients.